format-version: 1.0 date: 25:04:2007 19:30 saved-by: gocvs auto-generated-by: OBO-Edit subsetdef: goslim_generic "Generic GO slim" subsetdef: goslim_goa "GOA and proteome slim" subsetdef: goslim_plant "Plant GO slim" subsetdef: goslim_yeast "Yeast GO slim" subsetdef: gosubset_prok "Prokaryotic GO subset" default-namespace: gene_ontology remark: geneontology.org version: Revision: 4.231 [Term] id: GO:0000001 name: mitochondrion inheritance namespace: biological_process def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764] exact_synonym: "mitochondrial inheritance" [] is_a: GO:0048308 ! organelle inheritance is_a: GO:0048311 ! mitochondrion distribution [Term] id: GO:0000002 name: mitochondrial genome maintenance namespace: biological_process def: "The maintenance of the structure and integrity of the mitochondrial genome." [GOC:ai] is_a: GO:0007005 ! mitochondrion organization and biogenesis [Term] id: GO:0000003 name: reproduction namespace: biological_process alt_id: GO:0019952 alt_id: GO:0050876 def: "The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism." [GOC:go_curators, GOC:isa_complete, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_plant subset: gosubset_prok exact_synonym: "reproductive physiological process" [] is_a: GO:0008150 ! biological_process [Term] id: GO:0000005 name: ribosomal chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function." [GOC:jl, PMID:12150913] comment: This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function. To update annotations, consider biological_process term 'ribosome biogenesis and assembly ; GO:0042254' or its children and molecular_function term 'unfolded protein binding ; GO:0051082'. is_obsolete: true [Term] id: GO:0000006 name: high affinity zinc uptake transporter activity namespace: molecular_function def: "Catalysis of the reaction: Zn2+(out) = Zn2+(in), probably powered by proton motive force." [TC:2.A.5.1.1] xref_analog: TC:2.A.5.1.1 is_a: GO:0005385 ! zinc ion transporter activity [Term] id: GO:0000007 name: low-affinity zinc ion transporter activity namespace: molecular_function is_a: GO:0005385 ! zinc ion transporter activity [Term] id: GO:0000008 name: thioredoxin namespace: molecular_function alt_id: GO:0000013 def: "OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol." [GOC:kd] comment: This term was made obsolete because it represents gene products. To update annotations, consider molecular_function term 'thiol-disulfide exchange intermediate activity ; GO:0030508'. is_obsolete: true [Term] id: GO:0000009 name: alpha-1,6-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,6-linkage." [GOC:mcc, PMID:2644248] xref_analog: EC:2.4.1.- is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000010 name: trans-hexaprenyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-heptaprenyl diphosphate." [EC:2.5.1.30] subset: gosubset_prok xref_analog: EC:2.5.1.30 xref_analog: MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0000011 name: vacuole inheritance namespace: biological_process def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069] is_a: GO:0007033 ! vacuole organization and biogenesis is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0000012 name: single strand break repair namespace: biological_process def: "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html] subset: gosubset_prok is_a: GO:0006281 ! DNA repair [Term] id: GO:0000014 name: single-stranded DNA specific endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:mah] is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0000015 name: phosphopyruvate hydratase complex namespace: cellular_component def: "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok exact_synonym: "enolase complex" [] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0000016 name: lactase activity namespace: molecular_function def: "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." [EC:3.2.1.108] xref_analog: EC:3.2.1.108 xref_analog: MetaCyc:LACTASE-RXN xref_analog: Reactome:20536 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0000017 name: alpha-glucoside transport namespace: biological_process def: "The directed movement of alpha-glucosides into, out of, within or between cells. Alpha-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0042946 ! glucoside transport [Term] id: GO:0000018 name: regulation of DNA recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA recombination, the processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0051052 ! regulation of DNA metabolic process relationship: part_of GO:0006310 ! DNA recombination [Term] id: GO:0000019 name: regulation of mitotic recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators] narrow_synonym: "regulation of recombination within rDNA repeats" [] is_a: GO:0000018 ! regulation of DNA recombination relationship: part_of GO:0006312 ! mitotic recombination [Term] id: GO:0000020 name: negative regulation of recombination within rDNA repeats namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it describes a substrate-specific process. To update annotations, consider biological_process term 'negative regulation of mitotic recombination ; GO:0045950'. is_obsolete: true [Term] id: GO:0000022 name: mitotic spindle elongation namespace: biological_process def: "Lengthening of the distance between poles of the mitotic spindle." [GOC:mah] exact_synonym: "spindle elongation during mitosis" [] is_a: GO:0051231 ! spindle elongation relationship: part_of GO:0007052 ! mitotic spindle organization and biogenesis [Term] id: GO:0000023 name: maltose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok exact_synonym: "malt sugar metabolic process" [] exact_synonym: "malt sugar metabolism" [] exact_synonym: "maltose metabolism" [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0000024 name: maltose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok exact_synonym: "malt sugar biosynthesis" [] exact_synonym: "malt sugar biosynthetic process" [] exact_synonym: "maltose anabolism" [] exact_synonym: "maltose biosynthesis" [] exact_synonym: "maltose formation" [] exact_synonym: "maltose synthesis" [] is_a: GO:0000023 ! maltose metabolic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0000025 name: maltose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok exact_synonym: "malt sugar catabolic process" [] exact_synonym: "malt sugar catabolism" [] exact_synonym: "maltose breakdown" [] exact_synonym: "maltose degradation" [] narrow_synonym: "maltose hydrolysis" [] xref_analog: MetaCyc:MALTOSECAT-PWY is_a: GO:0000023 ! maltose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0000026 name: alpha-1,2-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,2-linkage." [GOC:mcc, PMID:10521541] xref_analog: EC:2.4.1.- is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000027 name: ribosomal large subunit assembly and maintenance namespace: biological_process def: "The maintenance and assembly of the large ribosomal subunit from its constituent parts." [GOC:jl] subset: gosubset_prok is_a: GO:0042257 ! ribosomal subunit assembly relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis and assembly [Term] id: GO:0000028 name: ribosomal small subunit assembly and maintenance namespace: biological_process def: "The maintenance and assembly of the small ribosomal subunit from its constituent parts." [GOC:jl] subset: gosubset_prok is_a: GO:0042257 ! ribosomal subunit assembly relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis and assembly [Term] id: GO:0000030 name: mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] subset: gosubset_prok xref_analog: EC:2.4.1.- xref_analog: Reactome:7672 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0000031 name: mannosylphosphate transferase activity namespace: molecular_function def: "Catalysis of the transfer of an mannosylphosphate group from one compound to another." [GOC:jl] is_a: GO:0016740 ! transferase activity [Term] id: GO:0000032 name: cell wall mannoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues other than as a moiety of nucleic acid." [GOC:ai] subset: gosubset_prok exact_synonym: "cell wall mannoprotein anabolism" [] exact_synonym: "cell wall mannoprotein biosynthesis" [] exact_synonym: "cell wall mannoprotein formation" [] exact_synonym: "cell wall mannoprotein synthesis" [] is_a: GO:0006057 ! mannoprotein biosynthetic process is_a: GO:0031506 ! cell wall glycoprotein biosynthetic process [Term] id: GO:0000033 name: alpha-1,3-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,3-linkage." [GOC:mcc, PMID:10521541] xref_analog: EC:2.4.1.- is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000034 name: adenine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3." [EC:3.5.4.2] subset: gosubset_prok xref_analog: EC:3.5.4.2 xref_analog: MetaCyc:ADENINE-DEAMINASE-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0000035 name: acyl binding namespace: molecular_function def: "Interacting selectively with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok broad_synonym: "acyl-CoA or acyl binding" [] is_a: GO:0005488 ! binding [Term] id: GO:0000036 name: acyl carrier activity namespace: molecular_function subset: gosubset_prok is_a: GO:0005386 ! carrier activity [Term] id: GO:0000038 name: very-long-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fatty acids with a chain length of C18 or greater." [GOC:hjd] subset: gosubset_prok exact_synonym: "very-long-chain fatty acid metabolism" [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0000039 name: plasma membrane long-chain fatty acid transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a gene product and it contains component information. To update annotations, consider cellular_component term 'plasma membrane ; GO:0005886' or its children and molecular_function term 'long-chain fatty acid transporter activity ; GO:0005324' or its children. is_obsolete: true [Term] id: GO:0000040 name: low affinity iron ion transport namespace: biological_process is_a: GO:0006826 ! iron ion transport [Term] id: GO:0000041 name: transition metal ion transport namespace: biological_process def: "The directed movement of transition metal ions into, out of, within or between cells. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok exact_synonym: "transition metal transport" [] is_a: GO:0030001 ! metal ion transport [Term] id: GO:0000042 name: protein targeting to Golgi namespace: biological_process def: "The process of directing proteins towards the Golgi using signals contained within the protein." [GOC:ai] exact_synonym: "protein-Golgi targeting" [] is_a: GO:0000301 ! retrograde transport, vesicle recycling within Golgi is_a: GO:0006605 ! protein targeting [Term] id: GO:0000044 name: ascorbate stabilization namespace: biological_process def: "The reduction of the ascorbate free radical to a stable form." [GOC:ai] subset: gosubset_prok exact_synonym: "vitamin C stabilization" [] is_a: GO:0006118 ! electron transport [Term] id: GO:0000045 name: autophagic vacuole formation namespace: biological_process def: "The formation of a double membrane-bound structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [PMID:9412464] exact_synonym: "autophagosome biosynthesis" [] exact_synonym: "autophagosome formation" [] is_a: GO:0006996 ! organelle organization and biogenesis relationship: part_of GO:0016236 ! macroautophagy [Term] id: GO:0000046 name: autophagic vacuole fusion namespace: biological_process def: "The fusion of an autophagic vacuole with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bound structures (autophagic bodies) appear in the vacuole." [PMID:11099404] narrow_synonym: "fusion of autophagosome with lysosome" [] is_a: GO:0048284 ! organelle fusion relationship: part_of GO:0016236 ! macroautophagy [Term] id: GO:0000047 name: Rieske iron-sulfur protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. To update annotations, consider molecular_function term 'electron carrier activity ; GO:0009055' or its children. exact_synonym: "Rieske iron-sulphur protein" [] is_obsolete: true [Term] id: GO:0000048 name: peptidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2)." [EC:2.3.2.12, PMID:11433365, PMID:9242921] xref_analog: EC:2.3.2.12 xref_analog: MetaCyc:PEPTIDYLTRANSFERASE-RXN xref_analog: Reactome:20610 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0000049 name: tRNA binding namespace: molecular_function def: "Interacting selectively with transfer RNA." [GOC:ai] subset: gosubset_prok is_a: GO:0003723 ! RNA binding [Term] id: GO:0000050 name: urea cycle namespace: biological_process alt_id: GO:0006594 alt_id: GO:0006871 def: "A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] exact_synonym: "ornithine cycle" [] exact_synonym: "urea biosynthesis" [] exact_synonym: "urea biosynthetic process" [] xref_analog: Reactome:211547 xref_analog: Reactome:221324 xref_analog: Reactome:229964 xref_analog: Reactome:237981 xref_analog: Reactome:244600 xref_analog: Reactome:249543 xref_analog: Reactome:252354 xref_analog: Reactome:255509 xref_analog: Reactome:258881 xref_analog: Reactome:262258 xref_analog: Reactome:265108 xref_analog: Reactome:268232 xref_analog: Reactome:273914 xref_analog: Reactome:280393 xref_analog: Reactome:282778 xref_analog: Reactome:286409 xref_analog: Reactome:288203 xref_analog: Reactome:289764 xref_analog: Reactome:290323 xref_analog: Reactome:291648 xref_analog: Reactome:292335 xref_analog: Reactome:293622 xref_analog: Reactome:70635 is_a: GO:0019627 ! urea metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0000051 name: urea cycle intermediate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok exact_synonym: "urea cycle intermediate metabolism" [] is_a: GO:0008152 ! metabolic process relationship: part_of GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0000052 name: citrulline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok exact_synonym: "citrulline metabolism" [] is_a: GO:0000051 ! urea cycle intermediate metabolic process is_a: GO:0019794 ! nonprotein amino acid metabolic process [Term] id: GO:0000053 name: argininosuccinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving argininosuccinate, 2-(Nw-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] exact_synonym: "argininosuccinate metabolism" [] is_a: GO:0000051 ! urea cycle intermediate metabolic process [Term] id: GO:0000054 name: ribosome export from nucleus namespace: biological_process def: "The directed movement of a ribosome from the nucleus into the cytoplasm." [GOC:ai] exact_synonym: "ribosome export out of nucleus" [] exact_synonym: "ribosome transport from nucleus to cytoplasm" [] exact_synonym: "ribosome-nucleus export" [] is_a: GO:0051168 ! nuclear export relationship: part_of GO:0006611 ! protein export from nucleus relationship: part_of GO:0042254 ! ribosome biogenesis and assembly [Term] id: GO:0000055 name: ribosomal large subunit export from nucleus namespace: biological_process alt_id: GO:0000057 def: "The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah] exact_synonym: "ribosomal large subunit export out of nucleus" [] exact_synonym: "ribosomal large subunit transport from nucleus to cytoplasm" [] exact_synonym: "ribosomal large subunit-nucleus export" [] is_a: GO:0000054 ! ribosome export from nucleus [Term] id: GO:0000056 name: ribosomal small subunit export from nucleus namespace: biological_process alt_id: GO:0000058 def: "The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah] exact_synonym: "ribosomal small subunit export out of nucleus" [] exact_synonym: "ribosomal small subunit transport from nucleus to cytoplasm" [] exact_synonym: "ribosomal small subunit-nucleus export" [] is_a: GO:0000054 ! ribosome export from nucleus [Term] id: GO:0000059 name: protein import into nucleus, docking namespace: biological_process def: "The aggregation and bonding together of the nuclear localization signal of a protein with nuclear envelope proteins such as importins." [GOC:isa_complete, PMID:7878057] exact_synonym: "protein docking during protein import into nucleus" [] exact_synonym: "protein docking during protein transport from cytoplasm to nucleus" [] exact_synonym: "protein docking during protein-nucleus import" [] exact_synonym: "protein transport from cytoplasm to nucleus, docking" [] exact_synonym: "protein-nucleus import, docking" [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0006606 ! protein import into nucleus [Term] id: GO:0000060 name: protein import into nucleus, translocation namespace: biological_process def: "The vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] exact_synonym: "protein translocation during protein import into nucleus" [] exact_synonym: "protein translocation during protein transport from cytoplasm to nucleus" [] exact_synonym: "protein translocation during protein-nucleus import" [] exact_synonym: "protein transport from cytoplasm to nucleus, translocation" [] exact_synonym: "protein-nucleus import, translocation" [] is_a: GO:0065002 ! intracellular protein transport across a membrane relationship: part_of GO:0006606 ! protein import into nucleus [Term] id: GO:0000061 name: protein import into nucleus, substrate release namespace: biological_process def: "The disaggregation of a protein complex composed of the nuclear localization sequence and the importin alpha, and importin beta proteins." [PMID:9687515] exact_synonym: "protein substrate release during protein import into nucleus" [] exact_synonym: "protein substrate release during protein transport from cytoplasm to nucleus" [] exact_synonym: "protein substrate release during protein-nucleus import" [] exact_synonym: "protein transport from cytoplasm to nucleus, substrate release" [] exact_synonym: "protein-nucleus import, substrate release" [] is_a: GO:0043624 ! cellular protein complex disassembly relationship: part_of GO:0006606 ! protein import into nucleus [Term] id: GO:0000062 name: acyl-CoA binding namespace: molecular_function def: "Interacting selectively with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok broad_synonym: "acyl-CoA or acyl binding" [] is_a: GO:0005504 ! fatty acid binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0000064 name: L-ornithine transporter activity namespace: molecular_function def: "Enables the directed movement of L-ornithine, 2,5-diaminopentanoic acid, into, out of, within or between cells." [GOC:ai] subset: gosubset_prok related_synonym: "histidine/arginine/lysine/ornithine porter activity" [] xref_analog: Reactome:20635 is_a: GO:0015179 ! L-amino acid transporter activity [Term] id: GO:0000066 name: mitochondrial ornithine transport namespace: biological_process def: "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a mitochondrion." [GOC:ai] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0015822 ! ornithine transport [Term] id: GO:0000067 name: DNA replication and chromosome cycle namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful concept. To update annotations, consider biological_process terms 'chromosome organization and biogenesis ; GO:0051276' or its children, 'chromosome segregation ; GO:0007059' or its children, and 'DNA replication ; GO:0006260' or its children. subset: gosubset_prok is_obsolete: true [Term] id: GO:0000070 name: mitotic sister chromatid segregation namespace: biological_process alt_id: GO:0016359 def: "The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai] exact_synonym: "mitotic chromosome segregation" [] narrow_synonym: "mitotic sister-chromatid adhesion release" [] is_a: GO:0000819 ! sister chromatid segregation is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000072 name: M phase specific microtubule process namespace: biological_process def: "A microtubule-based process that occurs only during M phase of the cell cycle." [GOC:mah] exact_synonym: "M-phase specific microtubule process" [] is_a: GO:0007017 ! microtubule-based process relationship: part_of GO:0000279 ! M phase [Term] id: GO:0000073 name: spindle pole body separation namespace: biological_process alt_id: GO:0030475 def: "A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble." [GOC:sgd_curators] exact_synonym: "spindle pole body separation (sensu Fungi)" [] narrow_synonym: "spindle pole body separation (sensu Saccharomyces)" [] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051300 ! spindle pole body organization and biogenesis [Term] id: GO:0000074 name: regulation of progression through cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:go_curators] subset: gosubset_prok related_synonym: "cell cycle regulator" [] related_synonym: "RHEB small monomeric GTPase activity" [] related_synonym: "tumor suppressor" [] exact_synonym: "control of cell cycle progression" [] exact_synonym: "modulation of cell cycle progression" [] exact_synonym: "regulation of cell cycle progression" [] xref_analog: Reactome:156678 xref_analog: Reactome:156699 xref_analog: Reactome:156711 xref_analog: Reactome:162657 xref_analog: Reactome:204139 xref_analog: Reactome:209045 xref_analog: Reactome:209050 xref_analog: Reactome:211608 xref_analog: Reactome:213123 xref_analog: Reactome:218715 xref_analog: Reactome:218726 xref_analog: Reactome:221382 xref_analog: Reactome:222877 xref_analog: Reactome:227596 xref_analog: Reactome:230018 xref_analog: Reactome:235842 xref_analog: Reactome:235853 xref_analog: Reactome:238231 xref_analog: Reactome:239383 xref_analog: Reactome:243028 xref_analog: Reactome:243033 xref_analog: Reactome:244651 xref_analog: Reactome:245640 xref_analog: Reactome:248176 xref_analog: Reactome:248181 xref_analog: Reactome:249585 xref_analog: Reactome:250281 xref_analog: Reactome:251600 xref_analog: Reactome:252387 xref_analog: Reactome:253031 xref_analog: Reactome:254679 xref_analog: Reactome:255542 xref_analog: Reactome:256281 xref_analog: Reactome:257921 xref_analog: Reactome:258917 xref_analog: Reactome:259656 xref_analog: Reactome:261512 xref_analog: Reactome:262291 xref_analog: Reactome:264389 xref_analog: Reactome:265239 xref_analog: Reactome:267430 xref_analog: Reactome:267435 xref_analog: Reactome:268364 xref_analog: Reactome:280849 xref_analog: Reactome:282764 xref_analog: Reactome:285431 xref_analog: Reactome:285436 xref_analog: Reactome:286566 is_a: GO:0051726 ! regulation of cell cycle [Term] id: GO:0000075 name: cell cycle checkpoint namespace: biological_process def: "A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage." [GOC:mah, ISBN:0815316194] xref_analog: Reactome:212094 xref_analog: Reactome:221853 xref_analog: Reactome:230421 xref_analog: Reactome:238463 xref_analog: Reactome:245004 xref_analog: Reactome:249905 xref_analog: Reactome:252621 xref_analog: Reactome:255806 xref_analog: Reactome:259199 xref_analog: Reactome:262557 xref_analog: Reactome:265381 xref_analog: Reactome:268515 xref_analog: Reactome:274237 xref_analog: Reactome:280705 xref_analog: Reactome:282912 xref_analog: Reactome:286730 xref_analog: Reactome:69620 is_a: GO:0000074 ! regulation of progression through cell cycle [Term] id: GO:0000076 name: DNA replication checkpoint namespace: biological_process def: "A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:rn, PMID:11728327, PMID:12537518] is_a: GO:0031570 ! DNA integrity checkpoint is_a: GO:0032297 ! negative regulation of DNA replication initiation [Term] id: GO:0000077 name: DNA damage checkpoint namespace: biological_process def: "A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds." [PMID:11891124] narrow_synonym: "DNA damage response, signal transduction resulting in cell cycle arrest" [] is_a: GO:0031570 ! DNA integrity checkpoint is_a: GO:0042770 ! DNA damage response, signal transduction [Term] id: GO:0000078 name: cell morphogenesis checkpoint namespace: biological_process def: "A cell cycle checkpoint observed when aspects of polarity control are defective, which maintains coordination between the process of cellular morphogenesis and the nuclear events of the cell cycle. For example, in budding yeast cell-cycle delay or arrest is induced when aspects of bud formation are defective." [GOC:vw, PMID:14644188] is_a: GO:0000075 ! cell cycle checkpoint relationship: part_of GO:0000902 ! cell morphogenesis [Term] id: GO:0000079 name: regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators] exact_synonym: "regulation of CDK activity" [] is_a: GO:0000074 ! regulation of progression through cell cycle is_a: GO:0045859 ! regulation of protein kinase activity [Term] id: GO:0000080 name: G1 phase of mitotic cell cycle namespace: biological_process def: "Progression through G1 phase, one of two 'gap' phases in the mitotic cell cycle; G1 is the interval between the completion of mitosis and the beginning of DNA synthesis." [ISBN:0815316194] xref_analog: Reactome:212033 xref_analog: Reactome:221797 xref_analog: Reactome:230372 xref_analog: Reactome:238411 xref_analog: Reactome:69236 is_a: GO:0051318 ! G1 phase relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000082 name: G1/S transition of mitotic cell cycle namespace: biological_process def: "Progression from G1 phase to S phase of the mitotic cell cycle." [GOC:mah] xref_analog: Reactome:212021 xref_analog: Reactome:221784 xref_analog: Reactome:230362 xref_analog: Reactome:238403 xref_analog: Reactome:244953 xref_analog: Reactome:249850 xref_analog: Reactome:252607 xref_analog: Reactome:255745 xref_analog: Reactome:259140 xref_analog: Reactome:262495 xref_analog: Reactome:265325 xref_analog: Reactome:268498 xref_analog: Reactome:274174 xref_analog: Reactome:280647 xref_analog: Reactome:282899 xref_analog: Reactome:286666 xref_analog: Reactome:288375 xref_analog: Reactome:289876 xref_analog: Reactome:290408 xref_analog: Reactome:291794 xref_analog: Reactome:293774 xref_analog: Reactome:69206 is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000083 name: G1/S-specific transcription in mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed during the G1/S phase of the mitotic cell cycle." [GOC:mah] xref_analog: Reactome:69205 is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle [Term] id: GO:0000084 name: S phase of mitotic cell cycle namespace: biological_process def: "Progression through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place." [ISBN:0815316194] is_a: GO:0051320 ! S phase relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000085 name: G2 phase of mitotic cell cycle namespace: biological_process def: "Progression through G2 phase, one of two 'gap' phases in the mitotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of mitosis." [ISBN:0815316194] xref_analog: Reactome:211891 xref_analog: Reactome:221655 xref_analog: Reactome:230246 xref_analog: Reactome:238281 xref_analog: Reactome:244852 xref_analog: Reactome:249746 xref_analog: Reactome:268392 xref_analog: Reactome:274099 xref_analog: Reactome:280573 xref_analog: Reactome:68911 is_a: GO:0051319 ! G2 phase relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000086 name: G2/M transition of mitotic cell cycle namespace: biological_process def: "Progression from G2 phase to M phase of the mitotic cell cycle." [GOC:mah] xref_analog: Reactome:211972 xref_analog: Reactome:221737 xref_analog: Reactome:230316 xref_analog: Reactome:238398 xref_analog: Reactome:244912 xref_analog: Reactome:249804 xref_analog: Reactome:252543 xref_analog: Reactome:255721 xref_analog: Reactome:259114 xref_analog: Reactome:262473 xref_analog: Reactome:265322 xref_analog: Reactome:268466 xref_analog: Reactome:274171 xref_analog: Reactome:280644 xref_analog: Reactome:282855 xref_analog: Reactome:286663 xref_analog: Reactome:69275 is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000087 name: M phase of mitotic cell cycle namespace: biological_process def: "Progression through M phase, the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:mah, ISBN:0815316194] exact_synonym: "M-phase of mitotic cell cycle" [] xref_analog: Reactome:212043 xref_analog: Reactome:221806 xref_analog: Reactome:230379 xref_analog: Reactome:238418 xref_analog: Reactome:244995 xref_analog: Reactome:249877 xref_analog: Reactome:252596 xref_analog: Reactome:255795 xref_analog: Reactome:259176 xref_analog: Reactome:262532 xref_analog: Reactome:265359 xref_analog: Reactome:268488 xref_analog: Reactome:282892 xref_analog: Reactome:286702 xref_analog: Reactome:68886 is_a: GO:0000279 ! M phase relationship: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0000088 name: mitotic prophase namespace: biological_process def: "Progression through prophase, the initial stage of mitosis in which the chromosomes are condensed but are not yet attached to a mitotic spindle." [ISBN:0815316194] xref_analog: Reactome:211977 xref_analog: Reactome:221742 xref_analog: Reactome:230322 xref_analog: Reactome:238359 xref_analog: Reactome:244917 xref_analog: Reactome:249807 xref_analog: Reactome:252546 xref_analog: Reactome:255723 xref_analog: Reactome:259116 xref_analog: Reactome:262475 xref_analog: Reactome:268434 xref_analog: Reactome:286639 xref_analog: Reactome:68875 is_a: GO:0051324 ! prophase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000089 name: mitotic metaphase namespace: biological_process def: "Progression through metaphase, the stage of mitosis at which chromosomes are firmly attached to the mitotic spindle at its equator but have not yet segregated to opposite poles." [ISBN:0815316194] xref_analog: Reactome:68879 is_a: GO:0051323 ! metaphase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000090 name: mitotic anaphase namespace: biological_process def: "Progression through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other." [ISBN:0815316194] xref_analog: Reactome:68882 is_a: GO:0051322 ! anaphase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000091 name: mitotic anaphase A namespace: biological_process def: "Progression through anaphase A, the part of mitotic anaphase in which the kinetochore microtubules shorten as chromosomes move toward the spindle poles." [ISBN:0815316194] is_a: GO:0000090 ! mitotic anaphase [Term] id: GO:0000092 name: mitotic anaphase B namespace: biological_process def: "Progression through anaphase B, the part of mitotic anaphase in which the polar microtubules elongate and the two poles of the spindle move farther apart." [ISBN:0815316194] is_a: GO:0000090 ! mitotic anaphase [Term] id: GO:0000093 name: mitotic telophase namespace: biological_process def: "Progression through telophase, the last of the stages of mitosis; in the canonical cell cycle, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [ISBN:0721662544] is_a: GO:0051326 ! telophase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000094 name: septin assembly and septum formation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was not defined and the string name implied two separate processes. To update annotations, consider biological_process terms 'barrier septum formation ; GO:0000917' or its children, 'selection of site for barrier septum formation ; GO:0000918', and 'septin ring assembly ; GO:0000921'. is_obsolete: true [Term] id: GO:0000095 name: S-adenosylmethionine transporter activity namespace: molecular_function def: "Enables the directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism, into, out of, within or between cells." [GOC:ai] exact_synonym: "S-adenosyl methionine transporter activity" [] is_a: GO:0000099 ! sulfur amino acid transporter activity is_a: GO:0051184 ! cofactor transporter activity [Term] id: GO:0000096 name: sulfur amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai] subset: gosubset_prok exact_synonym: "sulfur amino acid metabolism" [] exact_synonym: "sulphur amino acid metabolic process" [] exact_synonym: "sulphur amino acid metabolism" [] is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0006790 ! sulfur metabolic process [Term] id: GO:0000097 name: sulfur amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] subset: gosubset_prok exact_synonym: "sulfur amino acid anabolism" [] exact_synonym: "sulfur amino acid biosynthesis" [] exact_synonym: "sulfur amino acid formation" [] exact_synonym: "sulfur amino acid synthesis" [] exact_synonym: "sulphur amino acid biosynthesis" [] exact_synonym: "sulphur amino acid biosynthetic process" [] is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0008652 ! amino acid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0000098 name: sulfur amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] subset: gosubset_prok exact_synonym: "sulfur amino acid breakdown" [] exact_synonym: "sulfur amino acid catabolism" [] exact_synonym: "sulfur amino acid degradation" [] exact_synonym: "sulphur amino acid catabolic process" [] exact_synonym: "sulphur amino acid catabolism" [] is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0009063 ! amino acid catabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0000099 name: sulfur amino acid transporter activity namespace: molecular_function def: "Enables the directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of, within or between cells." [GOC:ai] subset: gosubset_prok exact_synonym: "sulphur amino acid transporter activity" [] is_a: GO:0015171 ! amino acid transporter activity [Term] id: GO:0000100 name: S-methylmethionine transporter activity namespace: molecular_function def: "Enables the directed movement of S-methylmethionine into, out of, within or between cells." [GOC:ai] subset: gosubset_prok is_a: GO:0000099 ! sulfur amino acid transporter activity [Term] id: GO:0000101 name: sulfur amino acid transport namespace: biological_process def: "The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of, within or between cells." [GOC:ai] subset: gosubset_prok exact_synonym: "sulphur amino acid transport" [] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0000102 name: L-methionine porter activity namespace: molecular_function xref_analog: TC:2.A.3.8.4 is_a: GO:0005294 ! neutral L-amino acid porter activity is_a: GO:0015191 ! L-methionine transporter activity [Term] id: GO:0000103 name: sulfate assimilation namespace: biological_process def: "The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GOC:jl] subset: gosubset_prok exact_synonym: "sulphate assimilation" [] is_a: GO:0006791 ! sulfur utilization [Term] id: GO:0000104 name: succinate dehydrogenase activity namespace: molecular_function alt_id: GO:0019739 def: "Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor. No reaction with quinols." [EC:1.3.99.1, GOC:kd] subset: gosubset_prok exact_synonym: "fumarate reductase" [] xref_analog: EC:1.3.99.1 xref_analog: MetaCyc:SUCC-FUM-OXRED-RXN xref_analog: Reactome:21566 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0000105 name: histidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] subset: gosubset_prok exact_synonym: "histidine anabolism" [] exact_synonym: "histidine biosynthesis" [] exact_synonym: "histidine formation" [] exact_synonym: "histidine synthesis" [] xref_analog: MetaCyc:HISTSYN-PWY is_a: GO:0006547 ! histidine metabolic process is_a: GO:0009076 ! histidine family amino acid biosynthetic process [Term] id: GO:0000107 name: imidazoleglycerol-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + AICAR + L-glutamate." [MetaCyc:GLUTAMIDOTRANS-RXN] subset: gosubset_prok exact_synonym: "imidazoleglycerol phosphate synthase activity" [] broad_synonym: "glutamine amidotransferase:cyclase" [] xref_analog: EC:2.4.2.- xref_analog: MetaCyc:GLUTAMIDOTRANS-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0000108 name: repairosome namespace: cellular_component def: "A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage." [PMID:10681587, PMID:9852079] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000109 name: nucleotide-excision repair complex namespace: cellular_component def: "Any complex formed of proteins that act in nucleotide-excision repair." [PMID:10915862] comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex. is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000110 name: nucleotide-excision repair factor 1 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. exact_synonym: "NEF1 complex" [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000111 name: nucleotide-excision repair factor 2 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. exact_synonym: "NEF2 complex" [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000112 name: nucleotide-excision repair factor 3 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (Core TFIIH is composed of Rad3, Tfb1, Tfb2, Ssl1, and Tfb4. Note that Ssl2p is also called Rad25)." [PMID:10915862, PMID:14500720, PMID:7813015] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. exact_synonym: "NEF3 complex" [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000113 name: nucleotide-excision repair factor 4 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. exact_synonym: "NEF4 complex" [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000114 name: G1-specific transcription in mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed during the G1 phase of the mitotic cell cycle." [GOC:mah] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000080 ! G1 phase of mitotic cell cycle [Term] id: GO:0000115 name: S-phase-specific transcription in mitotic cell cycle namespace: biological_process def: "A cell cycle process that regulates transcription such that the target genes are transcribed during the S phase of the mitotic cell cycle." [GOC:mah] exact_synonym: "S-specific transcription in mitotic cell cycle" [] xref_analog: Reactome:69241 is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000084 ! S phase of mitotic cell cycle [Term] id: GO:0000116 name: G2-specific transcription in mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed during the G2 phase of the mitotic cell cycle." [GOC:mah] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000085 ! G2 phase of mitotic cell cycle [Term] id: GO:0000117 name: G2/M-specific transcription in mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed during the G2/M phase of the mitotic cell cycle." [GOC:mah] xref_analog: Reactome:69274 is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0000118 name: histone deacetylase complex namespace: cellular_component def: "Complex that possesses histone deacetylase activity." [GOC:mah] comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'. exact_synonym: "HDAC complex" [] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0000119 name: mediator complex namespace: cellular_component def: "A protein complex that enables the RNA polymerase II-general RNA polymerase II transcription factor complex to react to transcriptional activator proteins; also enhances the level of basal transcription." [PMID:10384286, PMID:11114191, PMID:8187178, PMID:9396788, PMID:9774831] narrow_synonym: "TRAP complex" [] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0000120 name: RNA polymerase I transcription factor complex namespace: cellular_component def: "A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I." [GOC:mah] is_a: GO:0005667 ! transcription factor complex is_a: GO:0044452 ! nucleolar part [Term] id: GO:0000121 name: glycerol-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol 1-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.21] xref_analog: EC:3.1.3.21 xref_analog: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphoric monoester hydrolase activity [Term] id: GO:0000122 name: negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators] exact_synonym: "down regulation of transcription from RNA polymerase II promoter" [] exact_synonym: "down-regulation of transcription from RNA polymerase II promoter" [] exact_synonym: "downregulation of transcription from RNA polymerase II promoter" [] exact_synonym: "negative regulation of transcription from Pol II promoter" [] narrow_synonym: "inhibition of transcription from RNA polymerase II promoter" [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent [Term] id: GO:0000123 name: histone acetyltransferase complex namespace: cellular_component def: "Complex that possesses histone acetyltransferase activity." [GOC:mah] comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'. exact_synonym: "histone acetylase complex" [] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0000124 name: SAGA complex namespace: cellular_component def: "A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [PMID:10637607] exact_synonym: "Spt-Ada-Gcn5-acetyltransferase complex" [] is_a: GO:0000123 ! histone acetyltransferase complex [Term] id: GO:0000125 name: PCAF complex namespace: cellular_component def: "A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs." [PMID:10637607] comment: See also the cellular component term 'SAGA complex ; GO:0000124'. is_a: GO:0000123 ! histone acetyltransferase complex [Term] id: GO:0000126 name: transcription factor TFIIIB complex namespace: cellular_component def: "A transcription factor for eukaryotic RNA polymerase III promoters that is an RNA polymerase binding protein." [GOC:mah, ISBN:0198547684] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0000127 name: transcription factor TFIIIC complex namespace: cellular_component def: "A heterotrimeric transcription factor for eukaryotic RNA polymerase III promoters." [GOC:mah, ISBN:0198547684] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0000128 name: flocculation namespace: biological_process def: "The non-sexual aggregation of single-celled organisms." [GOC:jl] subset: gosubset_prok is_a: GO:0051704 ! multi-organism process [Term] id: GO:0000131 name: incipient cellular bud site namespace: cellular_component def: "The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence." [GOC:clt] is_a: GO:0044424 ! intracellular part [Term] id: GO:0000132 name: establishment of mitotic spindle orientation namespace: biological_process alt_id: GO:0030607 alt_id: GO:0030609 def: "The processes that set the alignment of mitotic spindle relative to other cellular structures." [GOC:ems] exact_synonym: "establishment of spindle orientation during mitosis" [] exact_synonym: "mitotic spindle orientation" [] exact_synonym: "orienting of mitotic spindle" [] narrow_synonym: "mitotic spindle orientation (sensu Fungi)" [] narrow_synonym: "mitotic spindle orientation (sensu Saccharomyces)" [] is_a: GO:0040001 ! establishment of mitotic spindle localization is_a: GO:0051294 ! establishment of spindle orientation [Term] id: GO:0000133 name: polarisome namespace: cellular_component def: "Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p." [PMID:14734532, PMID:14998522, PMID:9632790] is_a: GO:0043234 ! protein complex is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0030427 ! site of polarized growth [Term] id: GO:0000135 name: septin checkpoint namespace: biological_process def: "A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic CDK. In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed." [PMID:9925642] is_a: GO:0000075 ! cell cycle checkpoint [Term] id: GO:0000136 name: alpha-1,6-mannosyltransferase complex namespace: cellular_component def: "A large, multiprotein complex with alpha-1,6 mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins." [GOC:mcc, PMID:10037752, PMID:11095735] is_a: GO:0031501 ! mannosyltransferase complex is_a: GO:0044431 ! Golgi apparatus part relationship: part_of GO:0000137 ! Golgi cis cisterna [Term] id: GO:0000137 name: Golgi cis cisterna namespace: cellular_component def: "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194] is_a: GO:0031985 ! Golgi cisterna [Term] id: GO:0000138 name: Golgi trans cisterna namespace: cellular_component def: "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194] is_a: GO:0031985 ! Golgi cisterna [Term] id: GO:0000139 name: Golgi membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] is_a: GO:0031090 ! organelle membrane is_a: GO:0044425 ! membrane part is_a: GO:0044431 ! Golgi apparatus part relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0000140 name: acylglycerone-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-palmitoylglycerol 3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H+." [EC:1.1.1.101] exact_synonym: "1-acyldihydroxyacetone-phosphate reductase" [] exact_synonym: "palmitoyldihydroxyacetone-phosphate reductase" [] xref_analog: EC:1.1.1.101 xref_analog: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN xref_analog: Reactome:21659 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000142 name: cellular bud neck contractile ring namespace: cellular_component def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis." [GOC:krc, PMID:16009555] exact_synonym: "contractile ring (sensu Saccharomyces)" [] exact_synonym: "neck ring" [] broad_synonym: "actomyosin ring (sensu Saccharomyces)" [] broad_synonym: "cytokinetic ring (sensu Saccharomyces)" [] is_a: GO:0005826 ! contractile ring relationship: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0000144 name: cellular bud neck septin ring namespace: cellular_component def: "A ring-shaped structure that forms at the site of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange." [GOC:krc, PMID:16009555] exact_synonym: "septin ring (sensu Saccharomyces)" [] is_a: GO:0000399 ! cellular bud neck septin structure is_a: GO:0005940 ! septin ring is_a: GO:0032161 ! cleavage apparatus septin structure [Term] id: GO:0000145 name: exocyst namespace: cellular_component def: "Protein complex peripherally associated with the plasma membrane that determines where secretory vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152] is_a: GO:0043234 ! protein complex is_a: GO:0044448 ! cell cortex part [Term] id: GO:0000146 name: microfilament motor activity namespace: molecular_function def: "Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] related_synonym: "myosin ATPase activity" [] exact_synonym: "actin filament motor activity" [GOC:dph] exact_synonym: "actin-filament motor activity" [] narrow_synonym: "muscle motor activity" [] is_a: GO:0003774 ! motor activity [Term] id: GO:0000147 name: actin cortical patch assembly namespace: biological_process def: "Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells." [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030866 ! cortical actin cytoskeleton organization and biogenesis [Term] id: GO:0000148 name: 1,3-beta-glucan synthase complex namespace: cellular_component def: "The complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain." [EC:2.4.1.34] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0000149 name: SNARE binding namespace: molecular_function def: "Interacting selectively with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] exact_synonym: "SNAP receptor binding" [] is_a: GO:0005515 ! protein binding [Term] id: GO:0000150 name: recombinase activity namespace: molecular_function def: "Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh] comment: Consider also annotating to the molecular function terms 'double-stranded DNA binding ; GO:0003690' and 'single-stranded DNA binding ; GO:0003697'. Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'. subset: gosubset_prok narrow_synonym: "strand transferase" [] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0000151 name: ubiquitin ligase complex namespace: cellular_component def: "A protein complex that includes a ubiquitin-protein ligase (E3) and other proteins that may confer substrate specificity on the complex." [PMID:9529603] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000152 name: nuclear ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the nucleus." [GOC:mah] is_a: GO:0000151 ! ubiquitin ligase complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000153 name: cytoplasmic ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the cytoplasm." [GOC:mah] is_a: GO:0000151 ! ubiquitin ligase complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000154 name: rRNA modification namespace: biological_process def: "The covalent alteration of one or more nucleotides within rRNA, resulting in a change in the properties of the rRNA." [GOC:jl] subset: gosubset_prok is_a: GO:0009451 ! RNA modification is_a: GO:0016072 ! rRNA metabolic process [Term] id: GO:0000155 name: two-component sensor activity namespace: molecular_function def: "Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell." [GOC:mah] subset: gosubset_prok exact_synonym: "two-component system sensor activity " [] narrow_synonym: "two-component sensor molecule" [] xref_analog: EC:2.7.3.- is_a: GO:0004673 ! protein histidine kinase activity is_a: GO:0004871 ! signal transducer activity [Term] id: GO:0000156 name: two-component response regulator activity namespace: molecular_function def: "Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell." [GOC:mah] subset: gosubset_prok is_a: GO:0004871 ! signal transducer activity is_a: GO:0030528 ! transcription regulator activity [Term] id: GO:0000158 name: protein phosphatase type 2A activity namespace: molecular_function alt_id: GO:0008600 def: "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. A protein serine/threonine phosphatase that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine." [EC:3.1.3.16, ISBN:0198547684] exact_synonym: "protein phosphatase type 2A, intrinsic catalyst activity" [] is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0000159 name: protein phosphatase type 2A complex namespace: cellular_component def: "A heterodimer with protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic and regulatory subunits." [GOC:mah, ISBN:0198547684] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000160 name: two-component signal transduction system (phosphorelay) namespace: biological_process def: "A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038] subset: gosubset_prok exact_synonym: "histidyl-aspartyl phosphorelay" [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0000161 name: MAPKKK cascade during osmolarity sensing namespace: biological_process def: "MAPKKK cascade involved in signal transduction in response to change in osmotic conditions." [PMID:9561267] exact_synonym: "osmolarity sensing, MAPKKK cascade" [] is_a: GO:0000165 ! MAPKKK cascade relationship: part_of GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0000162 name: tryptophan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684] subset: gosubset_prok exact_synonym: "tryptophan anabolism" [] exact_synonym: "tryptophan biosynthesis" [] exact_synonym: "tryptophan formation" [] exact_synonym: "tryptophan synthesis" [] xref_analog: MetaCyc:TRPSYN-PWY is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0009096 ! aromatic amino acid family biosynthetic process, anthranilate pathway is_a: GO:0046219 ! indolalkylamine biosynthetic process [Term] id: GO:0000163 name: protein phosphatase type 1 activity namespace: molecular_function alt_id: GO:0008598 def: "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. An ATP, magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) that consists of a catalytic subunit of 38 kDa and a modulator subunit of 23 kDa, which is subject to phosphorylation, thus activating the phosphatase." [GOC:mah, ISBN:0198547684] exact_synonym: "protein phosphatase type 1, intrinsic catalyst activity" [] xref_analog: Reactome:21718 is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0000164 name: protein phosphatase type 1 complex namespace: cellular_component def: "An ATP, magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) that consists of a catalytic subunit of 38 kDa and a modulator subunit of 23 kDa, which is subject to phosphorylation, thus activating the phosphatase." [GOC:mah, ISBN:0198547684] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000165 name: MAPKKK cascade namespace: biological_process def: "Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways." [GOC:mah, PMID:9561267] exact_synonym: "ERK/MAPK cascade" [] exact_synonym: "MAP kinase cascade" [] exact_synonym: "MAP kinase kinase kinase cascade" [] exact_synonym: "MAPK cascade" [] narrow_synonym: "MAPKKK cascade during sporulation (sensu Fungi)" [] narrow_synonym: "MAPKKK cascade during sporulation (sensu Saccharomyces)" [] xref_analog: Reactome:109869 xref_analog: Reactome:211967 xref_analog: Reactome:221732 xref_analog: Reactome:230313 xref_analog: Reactome:238351 xref_analog: Reactome:244909 xref_analog: Reactome:249802 xref_analog: Reactome:252619 xref_analog: Reactome:255804 xref_analog: Reactome:259197 xref_analog: Reactome:262555 xref_analog: Reactome:268509 xref_analog: Reactome:274234 xref_analog: Reactome:280703 xref_analog: Reactome:286727 is_a: GO:0007243 ! protein kinase cascade [Term] id: GO:0000166 name: nucleotide binding namespace: molecular_function def: "Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety." [GOC:mah, ISBN:0198547684] subset: goslim_generic subset: goslim_plant subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0000167 name: activation of MAPKKK activity during osmolarity sensing namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during osmolarity sensing." [PMID:9561267] exact_synonym: "activation of MAP kinase kinase kinase activity during osmolarity sensing" [] exact_synonym: "osmolarity sensing, activation of MAP kinase kinase kinase activity" [] exact_synonym: "osmolarity sensing, activation of MAPKKK activity" [] is_a: GO:0000185 ! activation of MAPKKK activity relationship: part_of GO:0000161 ! MAPKKK cascade during osmolarity sensing [Term] id: GO:0000168 name: activation of MAPKK activity during osmolarity sensing namespace: biological_process alt_id: GO:0007233 def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase during osmolarity sensing." [PMID:9561267] exact_synonym: "activation of MAP kinase kinase activity during osmolarity sensing" [] exact_synonym: "osmolarity sensing, activation of MAP kinase kinase activity" [] exact_synonym: "osmolarity sensing, activation of MAPKK activity" [] narrow_synonym: "activation of Pbs2 kinase" [] is_a: GO:0000186 ! activation of MAPKK activity relationship: part_of GO:0000161 ! MAPKKK cascade during osmolarity sensing [Term] id: GO:0000169 name: activation of MAPK activity during osmolarity sensing namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing." [PMID:9561267] exact_synonym: "osmolarity sensing, activation of MAPK activity" [] is_a: GO:0000187 ! activation of MAPK activity relationship: part_of GO:0000161 ! MAPKKK cascade during osmolarity sensing [Term] id: GO:0000170 name: sphingosine hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of sphingolipid long chain bases." [PMID:9556590] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0000171 name: ribonuclease MRP activity namespace: molecular_function def: "Catalysis of the first cleavage in rRNA transcript processing, also involved in mitochondrial RNA processing." [PMID:10690410] exact_synonym: "RNase MRP" [] is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0000172 name: ribonuclease MRP complex namespace: cellular_component def: "A ribonucleoprotein complex that performs the first cleavage in rRNA transcript processing and is also involved in mitochondrial RNA processing." [PMID:10690410] exact_synonym: "ribonuclease mitochondrial RNA processing complex" [] exact_synonym: "RNase MRP complex" [] is_a: GO:0030529 ! ribonucleoprotein complex [Term] id: GO:0000173 name: inactivation of MAPK activity during osmolarity sensing namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing." [PMID:9561267] exact_synonym: "osmolarity sensing, inactivation of MAPK" [] exact_synonym: "osmolarity sensing, termination of MAPK activity" [] exact_synonym: "termination of MAPK activity during osmolarity sensing" [] is_a: GO:0000188 ! inactivation of MAPK activity relationship: part_of GO:0000161 ! MAPKKK cascade during osmolarity sensing [Term] id: GO:0000174 name: inactivation of MAPK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. To update annotations, use biological_process term 'pheromone-dependent signal transduction during conjugation with cellular fusion ; GO:0000750'. is_obsolete: true [Term] id: GO:0000175 name: 3'-5'-exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] subset: gosubset_prok exact_synonym: "3'-5' exoribonuclease activity" [] xref_analog: EC:3.1.13.- is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0000176 name: nuclear exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791] is_a: GO:0000178 ! exosome (RNase complex) is_a: GO:0044428 ! nuclear part [Term] id: GO:0000177 name: cytoplasmic exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases found in the cytoplasm." [PMID:10465791] is_a: GO:0000178 ! exosome (RNase complex) is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000178 name: exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases." [PMID:10465791] comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies. is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000179 name: rRNA (adenine-N6,N6-)-dimethyltransferase activity namespace: molecular_function def: "Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410] subset: gosubset_prok xref_analog: EC:2.1.1.- is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity [Term] id: GO:0000180 name: cytosolic large ribosomal subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because more specific children exist. To update annotations, consider cellular_component terms 'cytosolic large ribosomal subunit (sensu Bacteria) ; GO:0009282' and 'cytosolic large ribosomal subunit (sensu Eukaryota) ; GO:0005842'. is_obsolete: true [Term] id: GO:0000181 name: cytosolic small ribosomal subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because more specific children exist. To update annotations, consider cellular_component terms 'cytosolic small ribosomal subunit (sensu Bacteria) ; GO:0009283' and 'cytosolic small ribosomal subunit (sensu Eukaryota) ; GO:0005843'. is_obsolete: true [Term] id: GO:0000182 name: rDNA binding namespace: molecular_function def: "Interacting selectively with DNA sequences encoding ribosomal RNA." [GOC:mah] exact_synonym: "ribosomal DNA binding" [] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0000183 name: chromatin silencing at rDNA namespace: biological_process def: "Repression of transcription of ribosomal DNA by the formation of heterochromatin." [PMID:10219245] exact_synonym: "chromatin silencing at ribosomal DNA" [] is_a: GO:0006342 ! chromatin silencing [Term] id: GO:0000184 name: mRNA catabolic process, nonsense-mediated decay namespace: biological_process def: "The nonsense-mediated mRNA decay pathway degrades mRNAs transcribed from genes in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:ma, PMID:10025395] subset: gosubset_prok exact_synonym: "mRNA breakdown, nonsense-mediated decay" [] exact_synonym: "mRNA catabolic process, nonsense-mediated" [] exact_synonym: "mRNA catabolism, nonsense-mediated" [] exact_synonym: "mRNA degradation, nonsense-mediated decay" [] exact_synonym: "nonsense-mediated mRNA decay" [] is_a: GO:0006402 ! mRNA catabolic process [Term] id: GO:0000185 name: activation of MAPKKK activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase." [PMID:9561267] exact_synonym: "activation of MAP kinase kinase kinase" [] narrow_synonym: "activation of MAPKKK during sporulation (sensu Fungi)" [] narrow_synonym: "activation of MAPKKK during sporulation (sensu Saccharomyces)" [] broad_synonym: "positive regulation of MAP kinase kinase kinase activity" [] broad_synonym: "positive regulation of MAPKKK activity" [] is_a: GO:0032147 ! activation of protein kinase activity relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000186 name: activation of MAPKK activity namespace: biological_process alt_id: GO:0007255 def: "The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK." [PMID:9561267] exact_synonym: "activation of MAP kinase kinase activity" [] exact_synonym: "activation of MAP/ERK kinase kinase" [] narrow_synonym: "activation of MAPKK during sporulation (sensu Fungi)" [] narrow_synonym: "activation of MAPKK during sporulation (sensu Saccharomyces)" [] broad_synonym: "positive regulation of MAPKK activity" [] xref_analog: Reactome:110049 xref_analog: Reactome:211601 xref_analog: Reactome:221376 xref_analog: Reactome:230014 xref_analog: Reactome:238032 xref_analog: Reactome:244648 xref_analog: Reactome:249583 is_a: GO:0032147 ! activation of protein kinase activity relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000187 name: activation of MAPK activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK." [PMID:9561267] exact_synonym: "activation of MAP kinase" [] narrow_synonym: "activation of MAPK during sporulation (sensu Fungi)" [] narrow_synonym: "activation of MAPK during sporulation (sensu Saccharomyces)" [] xref_analog: Reactome:112409 xref_analog: Reactome:212039 xref_analog: Reactome:221803 xref_analog: Reactome:230377 xref_analog: Reactome:238416 xref_analog: Reactome:244963 xref_analog: Reactome:249842 xref_analog: Reactome:252574 xref_analog: Reactome:255755 xref_analog: Reactome:259149 xref_analog: Reactome:262506 xref_analog: Reactome:268461 xref_analog: Reactome:274183 xref_analog: Reactome:280656 xref_analog: Reactome:286675 is_a: GO:0043406 ! positive regulation of MAPK activity relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000188 name: inactivation of MAPK activity namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase." [PMID:9561267] exact_synonym: "termination of MAPK activity" [] narrow_synonym: "inactivation of MAPK during sporulation (sensu Fungi)" [] narrow_synonym: "inactivation of MAPK during sporulation (sensu Saccharomyces)" [] is_a: GO:0043407 ! negative regulation of MAPK activity relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000189 name: nuclear translocation of MAPK namespace: biological_process def: "The directed movement of a MAP kinase to the nucleus upon activation." [PMID:9561267] xref_analog: Reactome:109867 xref_analog: Reactome:109868 xref_analog: Reactome:112353 xref_analog: Reactome:209891 xref_analog: Reactome:209896 xref_analog: Reactome:228348 xref_analog: Reactome:228351 xref_analog: Reactome:236568 xref_analog: Reactome:236573 xref_analog: Reactome:243599 xref_analog: Reactome:243605 xref_analog: Reactome:248698 xref_analog: Reactome:248703 xref_analog: Reactome:251790 xref_analog: Reactome:251793 xref_analog: Reactome:254938 xref_analog: Reactome:254943 xref_analog: Reactome:258208 xref_analog: Reactome:258211 xref_analog: Reactome:261726 xref_analog: Reactome:261729 xref_analog: Reactome:267714 xref_analog: Reactome:267717 xref_analog: Reactome:273179 xref_analog: Reactome:273186 xref_analog: Reactome:279660 xref_analog: Reactome:279666 xref_analog: Reactome:285768 xref_analog: Reactome:285771 is_a: GO:0000060 ! protein import into nucleus, translocation relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000190 name: MAPKKK cascade (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000191 name: activation of MAPKKK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000192 name: activation of MAPKK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000193 name: activation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000194 name: inactivation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000195 name: nuclear translocation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000196 name: MAPKKK cascade during cell wall biogenesis namespace: biological_process def: "Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase that occurs during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] exact_synonym: "cell wall biogenesis, MAPKKK cascade" [] is_a: GO:0000165 ! MAPKKK cascade relationship: part_of GO:0007047 ! cell wall organization and biogenesis [Term] id: GO:0000197 name: activation of MAPKKK activity during cell wall biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] exact_synonym: "activation of MAP kinase kinase kinase activity during cell wall biogenesis" [] exact_synonym: "cell wall biogenesis, activation of MAP kinase kinase kinase activity" [] exact_synonym: "cell wall biogenesis, activation of MAPKKK activity" [] is_a: GO:0000185 ! activation of MAPKKK activity relationship: part_of GO:0000196 ! MAPKKK cascade during cell wall biogenesis [Term] id: GO:0000198 name: activation of MAPKK activity during cell wall biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] exact_synonym: "activation of MAP kinase kinase activity during cell wall biogenesis" [] exact_synonym: "cell wall biogenesis, activation of MAP kinase kinase activity" [] exact_synonym: "cell wall biogenesis, activation of MAPKK activity" [] is_a: GO:0000186 ! activation of MAPKK activity relationship: part_of GO:0000196 ! MAPKKK cascade during cell wall biogenesis [Term] id: GO:0000199 name: activation of MAPK activity during cell wall biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] exact_synonym: "cell wall biogenesis, activation of MAPK activity" [] is_a: GO:0000187 ! activation of MAPK activity relationship: part_of GO:0000196 ! MAPKKK cascade during cell wall biogenesis [Term] id: GO:0000200 name: inactivation of MAPK activity during cell wall biogenesis namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] exact_synonym: "cell wall biogenesis, inactivation of MAPK activity" [] exact_synonym: "cell wall biogenesis, termination of MAPK activity" [] exact_synonym: "termination of MAPK activity during cell wall biogenesis" [] is_a: GO:0000188 ! inactivation of MAPK activity relationship: part_of GO:0000196 ! MAPKKK cascade during cell wall biogenesis [Term] id: GO:0000201 name: nuclear translocation of MAPK during cell wall biogenesis namespace: biological_process def: "The directed movement of a MAP kinase to the nucleus during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] exact_synonym: "cell wall biogenesis, nuclear translocation of MAPK" [] is_a: GO:0000189 ! nuclear translocation of MAPK relationship: part_of GO:0000196 ! MAPKKK cascade during cell wall biogenesis [Term] id: GO:0000202 name: MAPKKK cascade during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000203 name: activation of MAPKKK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000204 name: activation of MAPKK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000205 name: activation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000206 name: inactivation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000207 name: nuclear translocation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000208 name: nuclear translocation of MAPK during osmolarity sensing namespace: biological_process def: "The directed movement of a MAP kinase to the nucleus during osmolarity sensing." [PMID:9561267] exact_synonym: "osmolarity sensing, nuclear translocation of MAPK" [] is_a: GO:0000189 ! nuclear translocation of MAPK relationship: part_of GO:0000161 ! MAPKKK cascade during osmolarity sensing [Term] id: GO:0000209 name: protein polyubiquitination namespace: biological_process def: "Addition of multiple ubiquitin moieties to a protein, forming a ubiquitin chain." [ISBN:0815316194] related_synonym: "polyubiquitin" [] exact_synonym: "protein polyubiquitinylation" [] exact_synonym: "protein polyubiquitylation" [] is_a: GO:0016567 ! protein ubiquitination [Term] id: GO:0000210 name: NAD+ diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O = AMP + NMN." [EC:3.6.1.22] subset: gosubset_prok exact_synonym: "NAD diphosphatase activity" [] exact_synonym: "NAD pyrophosphatase activity" [] xref_analog: EC:3.6.1.22 xref_analog: MetaCyc:NADPYROPHOSPHAT-RXN is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0000211 name: protein degradation tagging activity namespace: molecular_function def: "OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction." [GOC:cl, ISBN:0815316194] comment: This term was made obsolete because it represents a biological process and a molecular function. To update annotations, consider biological_process terms 'modification-dependent protein catabolic process ; GO:0019941' or its children and 'protein ubiquitination during ubiquitin-dependent protein catabolic process ; GO:0042787' and molecular_function term 'protein binding ; GO:0005515' or its children. is_obsolete: true [Term] id: GO:0000212 name: meiotic spindle organization and biogenesis namespace: biological_process def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah] exact_synonym: "meiotic spindle organisation and biogenesis" [] exact_synonym: "spindle organization and biogenesis during meiosis" [] is_a: GO:0007051 ! spindle organization and biogenesis is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0000213 name: tRNA-intron endonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] exact_synonym: "tRNA-splicing endonuclease" [] xref_analog: EC:3.1.27.9 xref_analog: MetaCyc:3.1.27.9-RXN is_a: GO:0004549 ! tRNA-specific ribonuclease activity is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0000214 name: tRNA-intron endonuclease complex namespace: cellular_component def: "A complex that catalyses the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000215 name: tRNA 2'-phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate." [PMID:9148937] is_a: GO:0008665 ! 2'-phosphotransferase activity [Term] id: GO:0000216 name: M/G1 transition of mitotic cell cycle namespace: biological_process def: "Progression from M phase to G1 phase of the mitotic cell cycle." [GOC:mah] xref_analog: Reactome:211997 xref_analog: Reactome:221761 xref_analog: Reactome:230342 xref_analog: Reactome:238378 xref_analog: Reactome:244933 xref_analog: Reactome:249898 xref_analog: Reactome:252623 xref_analog: Reactome:255800 xref_analog: Reactome:259165 xref_analog: Reactome:262551 xref_analog: Reactome:265375 xref_analog: Reactome:274161 xref_analog: Reactome:280634 xref_analog: Reactome:286652 xref_analog: Reactome:68874 is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000217 name: DNA secondary structure binding namespace: molecular_function def: "Interacting selectively with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions." [GOC:krc] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0000219 name: vacuolar hydrogen-transporting ATPase namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. To update annotations, consider cellular_component term 'proton-transporting two-sector ATPase complex ; GO:0016469' or its children. exact_synonym: "V-ATPase" [] is_obsolete: true [Term] id: GO:0000220 name: hydrogen ion transporting ATPase V0 domain namespace: cellular_component def: "The integral domain of the V-type ATPase comprises the pore through the membrane, through which protons are translocated." [GOC:rb, PMID:10224039, TC:3.A.2.-.-] comment: Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit. is_a: GO:0016471 ! hydrogen-translocating V-type ATPase complex [Term] id: GO:0000221 name: hydrogen ion transporting ATPase V1 domain namespace: cellular_component def: "The peripheral domain of the V-type ATPase contains the section responsible for ATP hydrolysis." [GOC:rb, PMID:10224039, TC:3.A.2.-.-] comment: Note that this domain generally consists of eight subunits. is_a: GO:0016471 ! hydrogen-translocating V-type ATPase complex [Term] id: GO:0000222 name: plasma membrane hydrogen ion transporting ATPase V0 domain namespace: cellular_component is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0000223 name: plasma membrane hydrogen ion transporting ATPase V1 domain namespace: cellular_component is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0000224 name: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52] subset: gosubset_prok related_synonym: "peptide:N-glycanase" [] exact_synonym: "PNGase" [] xref_analog: EC:3.5.1.52 xref_analog: MetaCyc:3.5.1.52-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0000225 name: N-acetylglucosaminylphosphatidylinositol deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. The second step enzyme catalyzing the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane. Catalyzes the N-deacetylation of GlcNAc-PI to GlcN-PI." [EC:3.5.1.89] comment: Note that this function was formerly EC:3.1.1.69. xref_analog: EC:3.5.1.89 xref_analog: MetaCyc:3.1.1.69-RXN xref_analog: Reactome:22619 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0000226 name: microtubule cytoskeleton organization and biogenesis namespace: biological_process def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0000227 name: oxaloacetate carrier activity namespace: molecular_function xref_analog: TC:2.A.29.15.1 is_a: GO:0015131 ! oxaloacetate transporter activity [Term] id: GO:0000228 name: nuclear chromosome namespace: cellular_component def: "A chromosome found in the nucleus of a eukaryotic cell." [GOC:mah] subset: goslim_generic narrow_synonym: "nuclear interphase chromosome" [] is_a: GO:0005694 ! chromosome is_a: GO:0044428 ! nuclear part [Term] id: GO:0000229 name: cytoplasmic chromosome namespace: cellular_component def: "A chromosome found in the cytoplasm." [GOC:mah] subset: goslim_generic subset: gosubset_prok narrow_synonym: "cytoplasmic interphase chromosome" [] is_a: GO:0005694 ! chromosome is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000230 name: nuclear mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the nucleus during mitosis." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider cellular_component term 'condensed nuclear chromosome ; GO:0000794' or its children. is_obsolete: true [Term] id: GO:0000231 name: cytoplasmic mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cytoplasm during mitosis." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider cellular_component term 'condensed chromosome ; GO:0000793' or its children. is_obsolete: true [Term] id: GO:0000232 name: nuclear interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the nucleus during interphase." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider cellular_component term 'nuclear chromosome ; GO:0000228' or its children. is_obsolete: true [Term] id: GO:0000233 name: cytoplasmic interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cytoplasm during interphase." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations, consider cellular_component term 'cytoplasmic chromosome ; GO:0000229' or its children. is_obsolete: true [Term] id: GO:0000234 name: phosphoethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate." [EC:2.1.1.103] xref_analog: EC:2.1.1.103 xref_analog: MetaCyc:2.1.1.103-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0000235 name: astral microtubule namespace: cellular_component def: "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194] is_a: GO:0005876 ! spindle microtubule is_a: GO:0005881 ! cytoplasmic microtubule relationship: part_of GO:0005818 ! aster [Term] id: GO:0000236 name: mitotic prometaphase namespace: biological_process def: "Progression through prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:mah, ISBN:0198547684] xref_analog: Reactome:68877 is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000237 name: leptotene namespace: biological_process def: "Progression through the first stage of prophase I in meiosis, in which chromosomes first become visible." [ISBN:0198547684] is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000238 name: zygotene namespace: biological_process def: "Progression through the second stage of prophase I in meiosis, in which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [ISBN:0198547684] is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000239 name: pachytene namespace: biological_process def: "Progression through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [ISBN:0198547684] is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000240 name: diplotene namespace: biological_process def: "Progression through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [ISBN:0198547684] is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000241 name: diakinesis namespace: biological_process def: "Progression through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [ISBN:0198547684] is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000242 name: pericentriolar material namespace: cellular_component def: "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005813 ! centrosome [Term] id: GO:0000243 name: commitment complex namespace: cellular_component def: "The first portion of the spliceosome to assemble in mRNA splicing; in commitment complex formation the 5' and 3' splice sites are recognized by the U1 snRNP and the U2 snRNP auxiliary factor, respectively." [PMID:9159080] exact_synonym: "E complex" [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005681 ! spliceosome [Term] id: GO:0000244 name: assembly of spliceosomal tri-snRNP namespace: biological_process def: "The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex." [ISBN:0879695897, PMID:9452384] related_synonym: "MATa1 (A1) pre-mRNA splicing" [] broad_synonym: "snRNP recycling" [] is_a: GO:0022618 ! protein-RNA complex assembly relationship: part_of GO:0000387 ! spliceosomal snRNP biogenesis [Term] id: GO:0000245 name: spliceosome assembly namespace: biological_process def: "The aggregation and bonding together of the spliceosome, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892] is_a: GO:0022618 ! protein-RNA complex assembly relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0000246 name: delta24(24-1) sterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: ergosterol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3-beta-ol + NADPH + H+." [EC:1.3.1.71, PMID:10722850] subset: gosubset_prok exact_synonym: "D24(24-1)-sterol reductase activity" [] exact_synonym: "sterol delta-24(28) methylene reductase activity" [] exact_synonym: "sterol delta-24(28) reductase activity" [] xref_analog: EC:1.3.1.71 xref_analog: MetaCyc:1.3.1.71-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0000247 name: C-8 sterol isomerase activity namespace: molecular_function def: "Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols." [UniProtKB:P32352] exact_synonym: "delta-8-delta-7 sterol isomerase" [] xref_analog: EC:5.3.3.- is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0000248 name: C-5 sterol desaturase activity namespace: molecular_function def: "Catalysis of the introduction of a C-5 double bond in the B ring of ergosterol." [UniProtKB:P32353] exact_synonym: "sterol-C5-desaturase" [] is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0000249 name: C-22 sterol desaturase activity namespace: molecular_function def: "Catalysis of the formation of the C-22(23) double bond in the sterol side chain." [UniProtKB:P54781] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0000250 name: lanosterol synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus." [EC:5.4.99.7] subset: gosubset_prok exact_synonym: "2,3-epoxysqualene-lanosterol cyclase" [] exact_synonym: "OSC" [] exact_synonym: "oxidosqualene-lanosterol cyclase" [] xref_analog: EC:5.4.99.7 xref_analog: MetaCyc:LANOSTEROL-SYNTHASE-RXN xref_analog: Reactome:22668 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0000252 name: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H." [EC:1.1.1.170, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. related_synonym: "sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity" [] xref_analog: EC:1.1.1.- is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000253 name: 3-keto sterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + NADPH + H+." [EC:1.1.1.270, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. xref_analog: EC:1.1.1.- is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000254 name: C-4 methylsterol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H+ + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O." [EC:1.14.13.72, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. related_synonym: "methylsterol hydroxylase activity" [] related_synonym: "methylsterol monooxygenase activity" [] exact_synonym: "4-methylsterol oxidase activity" [] xref_analog: EC:1.14.13.- is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0000255 name: allantoin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism." [GOC:mah, ISBN:0198547684] subset: gosubset_prok exact_synonym: "allantoin metabolism" [] is_a: GO:0009308 ! amine metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0000256 name: allantoin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:mah, ISBN:0198547684] subset: gosubset_prok exact_synonym: "allantoin breakdown" [] exact_synonym: "allantoin catabolism" [] exact_synonym: "allantoin degradation" [] is_a: GO:0000255 ! allantoin metabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0000257 name: nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides." [EC:3.5.5.1, GOC:kd] subset: gosubset_prok xref_analog: EC:3.5.5.1 xref_analog: MetaCyc:3.5.5.1-RXN xref_analog: UM-BBD_enzymeID:e0283 is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles [Term] id: GO:0000258 name: isoleucine/valine:sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in)." [TC:2.A.26.1.1] comment: This term was made obsolete because it represents a multifunctional gene product. To update annotations, consider molecular_function terms 'L-isoleucine transporter activity ; GO:0015188', 'L-valine transporter activity ; GO:0005304', and 'sodium:amino acid symporter activity ; GO:0005283' or its children. is_obsolete: true [Term] id: GO:0000259 name: intracellular nucleoside transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell." [GOC:ai] comment: This term was made obsolete because it contains component and function information. To update annotations, use cellular_component term 'intracellular ; GO:0005622' and molecular_function term 'nucleoside transporter activity ; GO:0005337'. is_obsolete: true [Term] id: GO:0000260 name: hydrogen-translocating V-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.1, TC:3.A.2.2.3] comment: This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961'. is_obsolete: true [Term] id: GO:0000261 name: sodium-translocating V-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.2] comment: This term was made obsolete because it represents a gene product. To update annotations, use molecular_function term 'sodium-transporting ATPase activity, rotational mechanism ; GO:0046962'. is_obsolete: true [Term] id: GO:0000262 name: mitochondrial chromosome namespace: cellular_component def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah] related_synonym: "mitochondrial genome" [] narrow_synonym: "mitochondrial DNA" [] narrow_synonym: "mtDNA" [] is_a: GO:0005694 ! chromosome is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0042645 ! mitochondrial nucleoid [Term] id: GO:0000263 name: heterotrimeric G-protein GTPase, alpha-subunit namespace: molecular_function def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. To update annotations, consider cellular_component term 'heterotrimeric G-protein complex ; GO:0005834' and molecular_function term 'GTPase activity ; GO:0003924'. is_obsolete: true [Term] id: GO:0000264 name: heterotrimeric G-protein GTPase, beta-subunit namespace: molecular_function def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. To update annotations, consider cellular_component term 'heterotrimeric G-protein complex ; GO:0005834' and molecular_function term 'GTPase activity ; GO:0003924'. is_obsolete: true [Term] id: GO:0000265 name: heterotrimeric G-protein GTPase, gamma-subunit namespace: molecular_function def: "OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. To update annotations, consider cellular_component term 'heterotrimeric G-protein complex ; GO:0005834' and molecular_function term 'GTPase activity ; GO:0003924'. is_obsolete: true [Term] id: GO:0000266 name: mitochondrial fission namespace: biological_process def: "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192] exact_synonym: "mitochondrial division" [] is_a: GO:0007005 ! mitochondrion organization and biogenesis is_a: GO:0048285 ! organelle fission [Term] id: GO:0000267 name: cell fraction namespace: cellular_component def: "A generic term for parts of cells prepared by disruptive biochemical techniques." [GOC:ma] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. subset: gosubset_prok is_a: GO:0044464 ! cell part [Term] id: GO:0000268 name: peroxisome targeting sequence binding namespace: molecular_function alt_id: GO:0005051 def: "Interacting selectively with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome." [GOC:mah, ISBN:0879693568] exact_synonym: "PTS binding" [] narrow_synonym: "peroxisome targeting signal receptor" [] narrow_synonym: "PTS receptor" [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0000269 name: toxin export channel activity namespace: molecular_function xref_analog: TC:1.B.20.-.- is_a: GO:0015288 ! porin activity is_a: GO:0019534 ! toxin transporter activity [Term] id: GO:0000270 name: peptidoglycan metabolic process namespace: biological_process alt_id: GO:0009284 def: "The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok exact_synonym: "murein metabolic process" [] exact_synonym: "murein metabolism" [] exact_synonym: "peptidoglycan metabolism" [] is_a: GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0000271 name: polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages." [GOC:go_curators] subset: gosubset_prok exact_synonym: "glycan biosynthesis" [] exact_synonym: "glycan biosynthetic process" [] exact_synonym: "polysaccharide anabolism" [] exact_synonym: "polysaccharide biosynthesis" [] exact_synonym: "polysaccharide formation" [] exact_synonym: "polysaccharide synthesis" [] is_a: GO:0016051 ! carbohydrate biosynthetic process is_a: GO:0043284 ! biopolymer biosynthetic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0000272 name: polysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages." [GOC:go_curators] subset: gosubset_prok exact_synonym: "polysaccharide breakdown" [] exact_synonym: "polysaccharide catabolism" [] exact_synonym: "polysaccharide degradation" [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0043285 ! biopolymer catabolic process [Term] id: GO:0000273 name: lipoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipoic acid, 1,2-dithiolane-3-pentanoic acid, a coenzyme involved in oxidative decarboxylation of keto acids." [GOC:ai, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok exact_synonym: "lipoic acid metabolism" [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0000274 name: mitochondrial proton-transporting ATP synthase, stator stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core." [GOC:mtg_sensu, PMID:10838056] exact_synonym: "hydrogen-transporting ATP synthase, stator stalk (sensu Eukaryota)" [] exact_synonym: "proton-transporting ATP synthase, stator stalk (sensu Eukaryota)" [] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk relationship: part_of GO:0000276 ! mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [Term] id: GO:0000275 name: mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) namespace: cellular_component def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled." [GOC:mtg_sensu, PMID:10838056] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. exact_synonym: "proton-transporting ATP synthase complex, catalytic core F(1) (sensu Eukaryota)" [] broad_synonym: "hydrogen-transporting ATP synthase, F1 sector" [] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex [Term] id: GO:0000276 name: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) namespace: cellular_component def: "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056] exact_synonym: "proton-transporting ATP synthase complex, coupling factor F(0) (sensu Eukaryota)" [] exact_synonym: "proton-transporting ATP synthase complex, coupling factor F(o) (sensu Eukaryota)" [] broad_synonym: "hydrogen-transporting ATP synthase, F0 sector" [] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex [Term] id: GO:0000277 name: [cytochrome c]-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c." [EC:2.1.1.59] xref_analog: EC:2.1.1.59 xref_analog: MetaCyc:2.1.1.59-RXN is_a: GO:0016279 ! protein-lysine N-methyltransferase activity [Term] id: GO:0000278 name: mitotic cell cycle namespace: biological_process def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, in which a cell is duplicated without changing ploidy; comprises four successive phases called G1, S, G2, and M." [GOC:mah, ISBN:0815316194] xref_analog: Reactome:212083 xref_analog: Reactome:221841 xref_analog: Reactome:230408 xref_analog: Reactome:238450 xref_analog: Reactome:244991 xref_analog: Reactome:249871 xref_analog: Reactome:252608 xref_analog: Reactome:255794 xref_analog: Reactome:259188 xref_analog: Reactome:262544 xref_analog: Reactome:265374 xref_analog: Reactome:268486 xref_analog: Reactome:274210 xref_analog: Reactome:280680 xref_analog: Reactome:282900 xref_analog: Reactome:286715 xref_analog: Reactome:288392 xref_analog: Reactome:289890 xref_analog: Reactome:290421 xref_analog: Reactome:291802 xref_analog: Reactome:293782 xref_analog: Reactome:69278 is_a: GO:0007049 ! cell cycle [Term] id: GO:0000279 name: M phase namespace: biological_process def: "Progression through M phase, the part of the cell cycle comprising nuclear division and cytokinesis." [ISBN:0815316194] exact_synonym: "M-phase" [] is_a: GO:0022403 ! cell cycle phase [Term] id: GO:0000280 name: nuclear division namespace: biological_process def: "The partitioning of the nucleus and its genetic information." [GOC:bf, GOC:jl, http://www.biology-online.org/] related_synonym: "karyokinesis" [] is_a: GO:0009987 ! cellular process [Term] id: GO:0000281 name: cytokinesis after mitosis namespace: biological_process def: "The processes resulting in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:ai] is_a: GO:0000910 ! cytokinesis is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000087 ! M phase of mitotic cell cycle [Term] id: GO:0000282 name: cellular bud site selection namespace: biological_process def: "The specification of the site where a daughter cell will form, in organisms that reproduce by budding." [GOC:mah] comment: Note that this term was split from 'bud site selection/establishment of cell polarity (sensu Saccharomyces) ; GO:0007115' (sibling term 'establishment of cell polarity (sensu Saccharomyces) ; GO:0000283'). related_synonym: "bud scar accumulation" [] broad_synonym: "bud site selection/establishment of cell polarity (sensu Saccharomyces)" [] is_a: GO:0007105 ! cytokinesis, site selection is_a: GO:0030468 ! establishment of cell polarity (sensu Fungi) [Term] id: GO:0000284 name: shmoo orientation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is an organism specific term. The entire branch of the ontology was reorganized to be more generally applicable. To update annotations, use biological_process term 'cellular morphogenesis during conjugation with cellular fusion ; GO:0000753'. is_obsolete: true [Term] id: GO:0000285 name: 1-phosphatidylinositol-3-phosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [EC:2.7.1.150] exact_synonym: "phosphatidylinositol-3-phosphate 5-kinase activity" [] xref_analog: EC:2.7.1.150 xref_analog: MetaCyc:2.7.1.150-RXN is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity [Term] id: GO:0000286 name: alanine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+." [EC:1.4.1.1] subset: gosubset_prok xref_analog: EC:1.4.1.1 xref_analog: MetaCyc:ALANINE-DEHYDROGENASE-RXN is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0000287 name: magnesium ion binding namespace: molecular_function def: "Interacting selectively with magnesium (Mg) ions." [GOC:ai] subset: gosubset_prok exact_synonym: "magnesium binding" [] is_a: GO:0046872 ! metal ion binding [Term] id: GO:0000288 name: mRNA catabolic process, deadenylation-dependent decay namespace: biological_process def: "A major pathway of mRNA degradation, that proceeds through a series of ordered steps: poly(A) tail shortening, deadenylylation-dependent decapping, and decay of the transcript body, and that can regulate mRNA stability." [GOC:krc] subset: gosubset_prok exact